The Virtual Parkinsonian patient

The Virtual Parkinsonian patient

Blog Article

Abstract This study investigates the influence of the pharmacological nigrostriatal dopaminergic stimulation on the entire brain by analyzing EEG and deep electrodes, placed near the subthalamic nuclei, from 10 Parkinsonian patients before (OFF) and after (ON) L-Dopa administration.We characterize Quo Vadis, Homo Viator? / Journeys in Jože Hradil’s Faceless Pictures large-scale brain dynamics as the spatio-temporal spreading of aperiodic bursts.We then simulate the effects of L-Dopa utilizing a novel neural-mass model that includes the local dopamine concentration.

Whole-brain dynamics are simulated for different dopaminergic tones, generating predictions for the expected dynamics, to be compared with empirical EEG and deep electrode data.To this end, we invert the model and infer the most likely dopaminergic tone from empirical data, correctly identifying a higher Dopaminergic tone in the ON-state, and a lower dopaminergic tone in the OFF-state, for each patient.In conclusion, we successfully infer the dopaminergic tone by integrating anatomical and functional knowledge into physiological predictions, using solid ground Designing training programs for the development of emotional intelligence in adolescents with behavioral problems truth to validate our findings.